Europe's Specialist for Complex, Commercially Unavailable Molecules

From First-Time Synthesis and Route Scouting to Process Development and Scale-Up from mg to kg

Pharmaceutical companies, biotech start-ups, materials innovators, and research organizations frequently face the same challenge:

The required molecule is simply not available on the market.

Or the published synthetic route is not reproducible, not scalable, or not economically viable.

This is exactly where ChiroBlock comes in.

For more than 25 years, we have specialized in solving synthesis challenges that other providers often decline. Our expertise lies in the development of custom synthetic routes, first-time synthesis projects, process optimization, and scalable manufacturing solutions for complex and commercially unavailable compounds.

✔ 25+ years of experience

✔ 100,000+ successful syntheses

✔ 1,000+ customers worldwide

✔ ISO 9001-certified quality management

✔ Strict NDA/CDA & IP protection

✔ Fee-for-Result contract options available

Request a Free Project Evaluation

What Makes Complex Molecules Challenging?

Many advanced compounds present significant scientific and technical challenges, including:

• No published synthetic route available
• Unknown reactivity or reaction behavior
• Difficult selectivity requirements
• Unstable intermediates
• Challenging scale-up characteristics
• Limited availability of starting materials

Typical Applications and Synthesis Challenges

ChiroBlock supports projects involving:

• First-time synthesis of novel molecules
• Reference compounds and analytical standards
• Metabolites
• API impurities
• Isotopically labeled compounds
• Functional and advanced materials
• Catalysts
• Research reagents

Why Customers Choose ChiroBlock for Difficult Molecules

First-Time Synthesis Instead of Catalog Chemistry

Our focus is not on selling catalog products.

We specialize in developing synthetic routes and manufacturing compounds that are not commercially available.

Whether you require a proof-of-concept molecule, a reference standard, a metabolite, or a novel functional material, we develop a tailored solution for your project.

Technology-Agnostic Problem Solving

We do not sell a specific technology.

We solve chemistry problems.

Depending on the project requirements, our scientists utilize:

• Flow Chemistry
• Photochemistry
• Enzymatic Reactions
• High-Pressure Chemistry
• Organometallic Chemistry
• Enantioselective Synthesis

This technology-independent approach allows us to identify the most efficient and scientifically appropriate route for each target molecule.

Fee-for-Result Contract Models

For selected projects, we are prepared to share technical development risks.

With our Fee-for-Result model, you only pay upon successful delivery of the agreed compound.

Learn More About Pricing & Contract Models

Our Workflow for Complex Molecules

1. Molecule Assessment

Structure evaluation

Literature review

Risk assessment

↓

2. Route Scouting

Literature analysis

Patent review

Alternative route identification

↓

3. First-Time Synthesis

Proof of Concept

Route optimization

↓

4. Scale-Up

mg → g → kg

↓

5. Supply Chain Support

Reliable long-term supply

From First-Time Synthesis to Production

Scientifically Proven Expertise

Why We Can Only Mention a Limited Number of Customers

The majority of our chemical custom synthesis projects are conducted under strict confidentiality agreements (NDA/CDA).

Therefore, customer names, project details, and proprietary data are generally not disclosed.

The references and case studies we publish originate exclusively from peer-reviewed scientific publications in which ChiroBlock has been explicitly acknowledged as a synthesis partner.

View Publications & Scientific References

Technological Capabilities

Synthesis Technologies

• Flow Chemistry
• Photochemistry
• Ozone Chemistry
• High-Pressure Chemistry
• Biocatalysis
• Enantioselective Synthesis
• Organometallic Chemistry

Purification Technologies

• Chromatography
• Crystallization
• Distillation
• Racemate Separation

Analytical Capabilities

• NMR
• HPLC
• Chiral HPLC
• MS
• GC-MS
• SEC

Which Projects Are Best Suited for ChiroBlock?

ChiroBlock is particularly well suited for:

• Commercially unavailable molecules
• Research reagents
• Reference compounds
• API impurities
• Metabolites
• Isotopically labeled compounds
• Functional materials
• Proof-of-concept molecules

Frequently Asked Questions

Find answers to the most common questions regarding chemical custom synthesis, contract research, pricing models, route scouting, process development, and scale-up in our FAQ section.

If you require additional information, our synthesis experts are happy to assist.

Visit the FAQ Section

Do You Need a Molecule That Is Not Commercially Available?

Talk to Europe's specialists for complex molecules.

✔ First-Time Synthesis

✔ Route Scouting

✔ Process Development

✔ Scale-Up

✔ Reliable Supply

Discuss Your Project with a Synthesis Expert And Request a Custom Synthesis Quote!