Synthesis of research reagents for academia

Trusted Chemical Custom Synthesis Partner for Universities, Research Institutes & Innovation-Driven Laboratories

For more than 25 years, ChiroBlock has been a trusted expert in the synthesis of new research reagents for academic R&D, supporting universities, scientific institutes, and advanced research groups worldwide. We specialize in the custom synthesis of complex, novel, and commercially unavailable molecules required for cutting-edge research in pharmaceuticals, biotechnology, catalysis, functional materials, and synthetic chemistry.

Our chemical synthesis service for academic R&D enables researchers to access tailor-made molecules that are not available from standard suppliers. Whether you require novel reference compounds, labeled molecules, screening reagents, API impurities, or proof-of-concept building blocks, our team develops reliable, reproducible, and scalable synthesis solutions from mg to kg scale.

✔ Complex & non-commercial research molecules
✔ Scalable synthesis routes (mg → kg)
✔ Full analytical documentation & reproducibility
✔ Confidential & IP-secure collaboration
✔ Risk-shared projects: No success – no cost

Discuss Your Academic R&D Project with Our Scientists

Why Researchers Choose ChiroBlock for the Synthesis of New Research Reagents for Academic R&D

➥ 100% Focus on Chemical Custom Synthesis

We do not sell catalog chemicals.
We develop tailor-made synthesis solutions for highly specialized research projects.

➥ Advanced Synthetic Chemistry Expertise

Our scientists use a broad range of modern technologies, including:

• Flow chemistry
• Photochemistry
• Enantioselective synthesis
• Catalysis & enzymatic transformations
• High-pressure & low-temperature chemistry

➥ End-to-End Scientific Support

From molecule evaluation to route scouting, optimization, purification, analytics, and supply—we support the complete lifecycle of your research reagent.

➥ Confidentiality & Scientific Integrity

Most projects involving the synthesis of new research reagents for academic R&D are linked to unpublished research and sensitive intellectual property. Therefore, we operate under strict confidentiality agreements and comprehensive IP protection standards.

Only scientific projects and publications independently published by our academic or industrial collaborators and explicitly referencing ChiroBlock can be disclosed publicly.

➥ Proven Expertise in Academic Chemical Synthesis

✔ 25+ years of synthetic chemistry experience
✔ More than 100,000 successful syntheses
✔ More than 1,000 global R&D customers
✔ ISO 9001-certified quality systems
✔ Trusted partner for complex and high-risk molecules

Our expertise in the synthesis of new research reagents for academic R&D has contributed to numerous scientific collaborations and peer-reviewed publications across multiple research disciplines.

➥ From Scientific Idea to Reliable Molecule

Researchers often face challenges such as:

• Molecules not commercially available
• Uncertain synthetic feasibility
• Limited internal synthesis capacity
• Difficult scale-up and reproducibility

ChiroBlock transforms molecular concepts into reliable synthesis solutions with reproducible quality and scalable processes.

➔  Start Your Academic Custom Synthesis Project Today
➔ Talk to a Synthetic Chemistry Expert
➔ Submit Your Molecule for Evaluation

Contact us today for a free evaluation

Recent Scientific Publications & References Involving Custom-Synthesized Molecules by ChiroBlock

For more than 25 years, ChiroBlock has specialized in the synthesis of commercially not available compounds for academic R&D, supporting universities, research institutes, and innovation-driven laboratories worldwide. Our expertise includes complex custom synthesis projects for pharmaceutical research, biotechnology, functional materials, and advanced synthetic chemistry, contributing to numerous scientific collaborations and peer-reviewed publications.

Because many projects involving the synthesis of commercially not available compounds for academic R&D are linked to unpublished research and sensitive intellectual property, we work under strict confidentiality and IP protection agreements. Therefore, we can only reference scientific projects and publications that have been independently published by our academic or industrial partners and explicitly mention ChiroBlock.

2026

★ Human biomonitoring of 2,4-di-tert-butylphenol: determination of the parent substance and a novel, specific metabolite in urine by UHPLC-MS/MS
Christoph Schmidtkunz, Katja Küpper, Frank Leßmann, Volkmar Wendisch, Oliver Seidelmann, Edgar Leibold, Melanie Flach, Isabell Schönrath & Gabriele Leng
Anal Bioanal Chem 418, 247–260 (2026)
https://doi.org/10.1007/s00216-025-06217-z

★ Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models
Joshua Abd Alla, Alexander Perhal, Xuebin Fu, Andreas Langer, Yasser el Faramawy, Ursula Quitterer
Cell Reports Medicine, 2026; 7
https://doi.org/10.1016/j.xcrm.2026.102707

★ Expanding the Genetic Code of an Animal with Two Non-Canonical Amino Acids
Jose Javier Vazquez Rodriguez, Sebastian Greiss
BioRxiv
https://www.biorxiv.org/content/10.64898/2026.01.20.700547v1.abstract
https://doi.org/10.64898/2026.01.20.700547

2025

★ In vitro evaluation of 4,4′-trimethylenedipyridinium and 4,4′-trimethylenedipiperidinium-based polycationic polymers against Acanthamoeba hatchetti
Tomas Rimkus, Stephan Reichl
Parasitology Research, Volume 124, 94 (2025)
https://doi.org/10.1007/s00436-025-08537-6

★ Photocaged FLP Recombinase for Precise Spatio-temporal Control of Gene Expression
Jose Javier Vazquez Rodriguez, Kieran Baxter, Sebastian Greiss
bioRxiv 2025.05.06.652468
https://doi.org/10.1101/2025.05.06.652468

★ A UPLC-MS/MS method for the determination of 2-nitro-1,3-propanediol, a metabolite of Bronopol, in human urine
Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Edgar Leibold and Gabriele Leng;
Anal. Methods, 2025,17, 7670-7677
https://doi.org/10.1039/D5AY00960J

★ A new class of natural anthelmintics targeting lipid metabolism
Hala Zahreddine Fahs, Fathima S. Refai, Suma Gopinadhan, Yasmine Moussa, Hin Hark Gan, Yamanappa Hunashal, Gennaro Battaglia, Patricia G. Cipriani, Claire Ciancia, Nabil Rahiman, Stephan Kremb, Xin Xie, Yanthe E. Pearson, Glenn L. Butterfoss, Rick M. Maizels, Gennaro Esposito, Antony P. Page, Kristin C. Gunsalus & Fabio Piano
Nat Commun 16, 305 (2025).
https://doi.org/10.1038/s41467-024-54965-w

★ Percutaneous absorption of climbazole: In vitro data from human skin
Catherine Champmartin, Matthieu Aubertin, Claire Seiwert, Frédéric Cosnier
Regulatory Toxicology and Pharmacology, Volume 162, November 2025, 105895
https://doi.org/10.1016/j.yrtph.2025.105895

★ TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains
Samuel A. Maiwald, Laura A. Schneider, Ronnald Vollrath, Joanna Liwocha, Matthew D. Maletic, Kirby N. Swatek, Monique P. C. Mulder & Brenda A. Schulman
Nature Structural & Molecular Biology volume 32, pages 1766–1775 (2025)
https://doi.org/10.1038/s41594-025-01561-1

★ The performance of an ophthalmic solution containing Poloxamer 407 and Polyquaternium 133 in reducing conjunctival bacterial load in patients receiving cataract surgery, a randomized trial
Alessio Martucci, Elisa Zanotto, Antonio Curtoni, Alessandro Tiezzi Appolloni, Andrea Corsi
European Journal of Ophthalmology. 2025;0(0).
https://doi.org/10.1177/11206721251375236

2024

★ Exposure of young German adults to the anti-dandruff agent climbazole from 2002 to 2022: Analysis of specific biomarkers in urinary samples
Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Till Weber, Gabriele Leng, Marike Kolossa-Gehring; Chemosphere, Volume 367, November 2024, 143611
https://doi.org/10.1016/j.chemosphere.2024.143611

★ Design and Synthesis of Red-Absorbing Fluoran Leuco Dyes Supported by Computational Screening
Deichmann, V.; Chercka, D.; Danner, D.; Rosselli, S.; Nelles, G.; Roberts, A.; Rodin, V.
ACS Omega 2024, 9, 32, 34567–34576
https://doi.org/10.1021/acsomega.4c02646

★ Identification and structural elucidation of an oxidation product generated during stability studies of Cabergoline drug product
Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhuth
Journal of Pharmaceutical and Biomedical Analysis, Volume 248, 15 September 2024, 116282
https://doi.org/10.1016/j.jpba.2024.116282

★ Activation of neurokinin-III receptors modulates human atrial TASK-1 currents
Felix Wiedmann, Amelie Paasche, Jendrik Nietfeld, Manuel Kraft
Journal of molecular and cellular cardiology, Volume 184, p. 26-36, November 2023
https://doi.org/10.1016/j.yjmcc.2023.09.010

★ Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome
El Hindi, K., Brachtendorf, S., Hartel, J. C., Renné, C., Birod, K., Schilling, K., ... & Grösch,
S. BBA-Molecular Basis of Disease, 1870 (2024), 166906
https://doi.org/10.1016/j.bbadis.2023.166906

★ First evidence of widespread anticoagulant rodenticide exposure of the Eurasian otter (Lutra lutra) in Germany
Julia Regnery, Simon Rohner, Julia Bachtin, Christel Möhlenkamp, Olaf Zinke,
Stefanie Jacob, Peter Wohlsein, Ursula Siebert, Georg Reifferscheid, Anton Friesen
Science of the Total Environment 907 (2024) 167938
https://doi.org/10.1016/j.scitotenv.2023.167938

★ Investigation of encapsulated water wire within self-assembled hydrophilic nanochannels, in a modified γ4-amino acid crystals: Tracking thermally induced changes of intermolecular interactions within a crystalline hydrate
Krishnayan Basuroy,Jose de Jesus Velazquez-Garcia, Simone Techert
Amino Acids (2024) 56:9
https://doi.org/10.1007/s00726-023-03372-4

★ Identification, Stability Studies and Structural Elucidation of an Oxidative Degradant of Cabergoline Drug Substance
Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhut
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4704462

★ Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles
Lisa Hahnefeld, Juliane Hackel, Sandra Trautmann, Carlo Angioni, Yannick Schreiber, Robert Gurke, Dominique Thomas, Sabine Wicker, Gerd Geisslinger, Irmgard Tegeder
https://doi.org/10.21203/rs.3.rs-4408378/v1

★ A specific and sensitive GC–MS-MS method for the quantitative determination of 2-phenoxyethanol and selected metabolites in human blood and urine
Jäger, T; Eckert, E.; Leibold, E.; Bader, M.
Journal of Analytical Toxicology, Volume 48, Issue 6, July 2024, Pages 419–428,
https://doi.org/10.1093/jat/bkae037

★ Nonengineered Fungus Provides a Shortcut from Cellulose to Bulk Erythro-isocitric Acid
Schlembach, I.; Bardl,B.; Regestein, R.; Rosenbaum, M.
ACS Sustainable Chem. Eng. 2024, 12, 9, 3408–3418
https://doi.org/10.1021/acssuschemeng.3c04664

★ All-in-one stability indicating polysorbate 20 degradation root-cause analytics via UPLC-QDa
Stefan Carle, Dirk-H. Evers, Elina Hagelskamp, Patrick Garidel, Julia Buske
Journal of Chromatography B 1232 (2024) 123955
https://doi.org/10.1016/j.jchromb.2023.123955

★ Optimierung der Chlorid-Kanalfunktion von mutantem Bestrophin-1
Huttner, L.
Dissertation Uni Regensburg
https://doi.org/10.5283/epub.58290 / https://epub.uni-regensburg.de/58290/

View all References and Scientific Publications here