For over two decades, ChiroBlock has supported international R&D teams with advanced chemical custom synthesis solutions for complex, novel, and non-commercially available molecules. Our work spans pharmaceutical research, biotechnology, functional materials, and specialty chemistry, contributing to numerous scientific collaborations and published research projects.

Because most chemical custom synthesis projects involve sensitive intellectual property and early-stage innovation, we operate primarily under strict confidentiality agreements and comprehensive IP protection standards. As a result, we are usually unable to publicly disclose customer identities, proprietary project information, or unpublished technical results.

Only projects and scientific publications that have been independently released by customers and explicitly reference ChiroBlock can be mentioned publicly.

This consistent commitment to discretion, scientific reliability, and secure collaboration has made ChiroBlock a trusted partner for organizations seeking professional expertise in chemical custom synthesis and applied synthetic chemistry.

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Recent Scientific Publications & References Involving Custom-Synthesized Molecules by ChiroBlock

2026

★ Human biomonitoring of 2,4-di-tert-butylphenol: determination of the parent substance and a novel, specific metabolite in urine by UHPLC-MS/MS
Christoph Schmidtkunz, Katja Küpper, Frank Leßmann, Volkmar Wendisch, Oliver Seidelmann, Edgar Leibold, Melanie Flach, Isabell Schönrath & Gabriele Leng
Anal Bioanal Chem 418, 247–260 (2026)
https://doi.org/10.1007/s00216-025-06217-z

★ Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models
Joshua Abd Alla, Alexander Perhal, Xuebin Fu, Andreas Langer, Yasser el Faramawy, Ursula Quitterer
Cell Reports Medicine, 2026; 7
https://doi.org/10.1016/j.xcrm.2026.102707

★ Expanding the Genetic Code of an Animal with Two Non-Canonical Amino Acids
Jose Javier Vazquez Rodriguez, Sebastian Greiss
BioRxiv
https://www.biorxiv.org/content/10.64898/2026.01.20.700547v1.abstract
https://doi.org/10.64898/2026.01.20.700547

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2025

★ In vitro evaluation of 4,4′-trimethylenedipyridinium and 4,4′-trimethylenedipiperidinium-based polycationic polymers against Acanthamoeba hatchetti
Tomas Rimkus, Stephan Reichl
Parasitology Research, Volume 124, 94 (2025)
https://doi.org/10.1007/s00436-025-08537-6

★ Photocaged FLP Recombinase for Precise Spatio-temporal Control of Gene Expression
Jose Javier Vazquez Rodriguez, Kieran Baxter, Sebastian Greiss
bioRxiv 2025.05.06.652468
https://doi.org/10.1101/2025.05.06.652468

★ A UPLC-MS/MS method for the determination of 2-nitro-1,3-propanediol, a metabolite of Bronopol, in human urine
Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Edgar Leibold and Gabriele Leng;
Anal. Methods, 2025,17, 7670-7677
https://doi.org/10.1039/D5AY00960J

★ A new class of natural anthelmintics targeting lipid metabolism
Hala Zahreddine Fahs, Fathima S. Refai, Suma Gopinadhan, Yasmine Moussa, Hin Hark Gan, Yamanappa Hunashal, Gennaro Battaglia, Patricia G. Cipriani, Claire Ciancia, Nabil Rahiman, Stephan Kremb, Xin Xie, Yanthe E. Pearson, Glenn L. Butterfoss, Rick M. Maizels, Gennaro Esposito, Antony P. Page, Kristin C. Gunsalus & Fabio Piano
Nat Commun 16, 305 (2025).
https://doi.org/10.1038/s41467-024-54965-w

★ Percutaneous absorption of climbazole: In vitro data from human skin
Catherine Champmartin, Matthieu Aubertin, Claire Seiwert, Frédéric Cosnier
Regulatory Toxicology and Pharmacology, Volume 162, November 2025, 105895
https://doi.org/10.1016/j.yrtph.2025.105895

★ TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains
Samuel A. Maiwald, Laura A. Schneider, Ronnald Vollrath, Joanna Liwocha, Matthew D. Maletic, Kirby N. Swatek, Monique P. C. Mulder & Brenda A. Schulman
Nature Structural & Molecular Biology volume 32, pages 1766–1775 (2025)
https://doi.org/10.1038/s41594-025-01561-1

★ The performance of an ophthalmic solution containing Poloxamer 407 and Polyquaternium 133 in reducing conjunctival bacterial load in patients receiving cataract surgery, a randomized trial
Alessio Martucci, Elisa Zanotto, Antonio Curtoni, Alessandro Tiezzi Appolloni, Andrea Corsi
European Journal of Ophthalmology. 2025;0(0).
https://doi.org/10.1177/11206721251375236

 

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2024

★ Exposure of young German adults to the anti-dandruff agent climbazole from 2002 to 2022: Analysis of specific biomarkers in urinary samples
Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Till Weber, Gabriele Leng, Marike Kolossa-Gehring; Chemosphere, Volume 367, November 2024, 143611
https://doi.org/10.1016/j.chemosphere.2024.143611

★ Design and Synthesis of Red-Absorbing Fluoran Leuco Dyes Supported by Computational Screening
Deichmann, V.; Chercka, D.; Danner, D.; Rosselli, S.; Nelles, G.; Roberts, A.; Rodin, V.
ACS Omega 2024, 9, 32, 34567–34576
https://doi.org/10.1021/acsomega.4c02646

★ Identification and structural elucidation of an oxidation product generated during stability studies of Cabergoline drug product
Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhuth
Journal of Pharmaceutical and Biomedical Analysis, Volume 248, 15 September 2024, 116282
https://doi.org/10.1016/j.jpba.2024.116282

★ Activation of neurokinin-III receptors modulates human atrial TASK-1 currents
Felix Wiedmann, Amelie Paasche, Jendrik Nietfeld, Manuel Kraft
Journal of molecular and cellular cardiology, Volume 184, p. 26-36, November 2023
https://doi.org/10.1016/j.yjmcc.2023.09.010

★ Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome
El Hindi, K., Brachtendorf, S., Hartel, J. C., Renné, C., Birod, K., Schilling, K., ... & Grösch,
S. BBA-Molecular Basis of Disease, 1870 (2024), 166906
https://doi.org/10.1016/j.bbadis.2023.166906

★ First evidence of widespread anticoagulant rodenticide exposure of the Eurasian otter (Lutra lutra) in Germany
Julia Regnery, Simon Rohner, Julia Bachtin, Christel Möhlenkamp, Olaf Zinke,
Stefanie Jacob, Peter Wohlsein, Ursula Siebert, Georg Reifferscheid, Anton Friesen
Science of the Total Environment 907 (2024) 167938
https://doi.org/10.1016/j.scitotenv.2023.167938

★ Investigation of encapsulated water wire within self-assembled hydrophilic nanochannels, in a modified γ4-amino acid crystals: Tracking thermally induced changes of intermolecular interactions within a crystalline hydrate
Krishnayan Basuroy,Jose de Jesus Velazquez-Garcia, Simone Techert
Amino Acids (2024) 56:9
https://doi.org/10.1007/s00726-023-03372-4

★ Identification, Stability Studies and Structural Elucidation of an Oxidative Degradant of Cabergoline Drug Substance
Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhut
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4704462

★ Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles
Lisa Hahnefeld, Juliane Hackel, Sandra Trautmann, Carlo Angioni, Yannick Schreiber, Robert Gurke, Dominique Thomas, Sabine Wicker, Gerd Geisslinger, Irmgard Tegeder
https://doi.org/10.21203/rs.3.rs-4408378/v1

★ A specific and sensitive GC–MS-MS method for the quantitative determination of 2-phenoxyethanol and selected metabolites in human blood and urine
Jäger, T; Eckert, E.; Leibold, E.; Bader, M.
Journal of Analytical Toxicology, Volume 48, Issue 6, July 2024, Pages 419–428,
https://doi.org/10.1093/jat/bkae037

★ Nonengineered Fungus Provides a Shortcut from Cellulose to Bulk Erythro-isocitric Acid
Schlembach, I.; Bardl,B.; Regestein, R.; Rosenbaum, M.
ACS Sustainable Chem. Eng. 2024, 12, 9, 3408–3418
https://doi.org/10.1021/acssuschemeng.3c04664

★ All-in-one stability indicating polysorbate 20 degradation root-cause analytics via UPLC-QDa
Stefan Carle, Dirk-H. Evers, Elina Hagelskamp, Patrick Garidel, Julia Buske
Journal of Chromatography B 1232 (2024) 123955
https://doi.org/10.1016/j.jchromb.2023.123955

★ Optimierung der Chlorid-Kanalfunktion von mutantem Bestrophin-1
Huttner, L.
Dissertation Uni Regensburg
https://doi.org/10.5283/epub.58290 / https://epub.uni-regensburg.de/58290/

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2023

★ Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans
Kai Nieschalke, Nick Bergau, Sönke Jessel, Albrecht Seidel, Susanne Baldermann, Monika Schreiner, Klaus Abraham, Alfonso Lampen, Bernhard H. Monien, Burkhard Kleuser, Hansruedi Glatt* and Fabian Schumacher*
Chem. Res. Toxicol. 2023, 36, 11, 1753–1767
https://doi.org/10.1021/acs.chemrestox.3c00212

★ Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome
El Hindi, K., Brachtendorf, S., Hartel, J. C., Renné, C., Birod, K., Schilling, K. & Grösch, S.
BBA-Molecular Basis of Disease, 1870 (2024), 166906
https://doi.org/10.1016/j.bbadis.2023.166906

★ Concentration-dependent inhibition of mesophilic PETases on poly(ethylene terephthalate) can be eliminated by enzyme engineering
Avilan, L., Lichtenstein, B. R., Koenig, G., Zahn, M., Allen, M. D., Oliveira, L., ... & Pickford, A. R. (2023).
ChemSusChem, e202202277.
https://doi.org/10.1002/cssc.202202277

★ Electrocatalytic Reduction of Aldonic Acids to Aldoses on Gold Electrodes
Wolfsgruber, M., Rodrigues, B. V., da Cruz, M. G., Bischof, R. H., Budnyk, S., Beele, B., ... & Slabon, A. (2022).
ACS Sustainable Chemistry & Engineering.
https://doi.org/10.1021/acssuschemeng.2c05576

★ Role of organogel chemistry on rheology and microstructure of molecular gels rationalized by Hansen solubility parameters
Hesami, M., Heßler, C., Schmidt, S., & Schmiedel, P. (2023).
Colloid and Polymer Science, 1-9.
https://doi.org/10.1007/s00396-023-05094-1

★ Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5
Laura A. Hehl, Daniel Horn-Ghetko, J. Rajan Prabu, Ronnald Vollrath, D. Tung Vu, David A. Pérez Berrocal, Monique P. C. Mulder, Gerbrand J. van der Heden van Noort & Brenda A. Schulman
Nature Chemical Biology volume 20, pages 190–200 (2024)
(2023). bioRxiv, 2023-06.
https://doi.org/10.1101/2023.06.06.543850

★ Lignin-Based Polyurethanes from the Blocked Isocyanate Approach: Synthesis and Characterization
Antonino, L. D., Sumerskii, I., Potthast, A., Rosenau, T., Felisberti, M. I., & dos Santos, D. J. (2023).
ACS Omega.
https://doi.org/10.1021/acsomega.3c03422

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2022

★ Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer
Madera, S., Izzo, F., Chervo, M. F., Dupont, A., Chiauzzi, V. A., Bruni, S., ... & Cordo Russo, R. I. (2022).
Cell death & disease, 13(5), 1-14.
https://doi.org/10.1038/s41419-022-04855-0

★ Control of topoisomerase II activity and chemotherapeutic inhibition by TCA cycle metabolites
Joyce H. Lee, Eric P. Mosher, Young-Sam Lee, Namandjé N. Bumpus, James M. Berger,
Cell Chemical Biology, Volume 29, Issue 3, 2022, Pages 476-489.e6,
https://doi.org/10.1016/j.chembiol.2021.08.014

★ Bioassay-directed analysis-based identification of relevant pyrrolizidine alkaloids
Louisse, J., Mulder, P.P.J., Gerssen, A. et al.
Arch Toxicol 96, 2299–2317 (2022).
https://doi.org/10.1007/s00204-022-03308-z

★ Using a quadruplet codon to expand the genetic code of an animal
Zhiyan Xi, Lloyd Davis, Kieran Baxter, Ailish Tynan, Angeliki Goutou, Sebastian Greiss,
Nucleic Acids Research, Volume 50, Issue 9, 20 May 2022, Pages 4801–4812,
https://doi.org/10.1093/nar/gkab1168

★ Snake Venom Hydrogels as a Rapid Hemostatic Agent for Uncontrolled Bleeding
Yegappan, R., Lauko, J., Wang, Z., Lavin, M. F., Kijas, A. W., Rowan, A. E.,
Adv. Healthcare Mater. 2022, 11, 2200574.
https://doi.org/10.1002/adhm.202200574

★ Reliable determination of the main metabolites of 2-phenoxyethanol in human blood and urine using LC-MS/MS analysis
Jäger, T., Eckert, E., Leibold, E., & Bader, M. (2022).
Analytical Methods.
https://doi.org/10.1039/D2AY01407F

★ Oxidation of monoterpenes studied in atmospheric simulation chambers
Hantschke, L. L. (2022).
(Doctoral dissertation, Forschungszentrum Jülich GmbH, Zentralbibliothek, Verlag).
https://kups.ub.uni-koeln.de/64066/

★ Visualization of structural intermediates in an E3-E3 ligase ubiquitylation cascade via cryo-EM
Horn-Ghetko, D. (2022).
(Doctoral dissertation, Technische Universität München).
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20220503-1639681-1-6

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2021

★ Engineering and evaluation of thermostable IsPETase variants for PET degradation
Stefan Brott, Lara Pfaff, Josephine Schuricht, Jan-Niklas Schwarz, Dominique Böttcher, Christoffel P. S. Badenhorst, Ren Wei, Uwe T. Bornscheuer
Engineering in Life Sciences, November 29th, 2021
https://doi.org/10.1002/elsc.202100105

★ A general solvent system for the analysis of lignosulfonates by 31P NMR
Gerhild K. Wurzer, a Markus Bacher, a Hubert Hettegger, a Ivan Sumerskii, a Oliver Musl, a Karin Fackler,b Robert H. Bischof, b Antje Potthast a and Thomas Rosenau *ac
Anal. Methods, 2021,13, 5502-5508
https://doi.org/10.1039/D1AY01241J

★ Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells
Isabella Damiani, Silvia Castiglioni, Alicja Sochaj-Gregorczyk, Fabrizia Bonacina, Irma Colombo, Valentina Rusconi, Jacek Otlewski, Alberto Corsini and Stefano Bellosta
Biology 2021, 10(8), 758;
https://doi.org/10.3390/biology10080758
✔ MC-Val-Cit-PABC-MMAE (maleimidocaprylvaline-citruline-p-amino-benzyloxycarbonyl-monomethyl auristatin E) (ChiroBlock GmbH)

★ A validated LC-MS/MS method for the quantification of climbazole metabolites in human urine
Christoph Schmidtkunz, Katja Küpper, WolfgangGries1, GabrieleLeng
Journal of Chromatography B, Volume 1173, 30 May 2021, 122677
https://www.sciencedirect.com/science/article/abs/pii/S1570023221001574
https://doi.org/10.1016/j.jchromb.2021.122677
✔ “The team at ChiroBlock are acknowledged for their expert consulting, synthesis and characterization of the reference substances.”

★ Geraniol – Determination of 8 carboxy geraniol, Hildebrandt acid, geranic acid, and 3 hydroxycitronellic acid in urine by UPLC MS/MS, Biomonitoring Method
T. Jäger1, S. Bäcker1, T. Brodbeck1, M. Bader1, G. Scherer2, M. Stöckelhuber2, T. Göen3,*, A. Hartwig4,* MAK Commission5,*
The MAK Collection for Occupational Health and Safety 2021, Vol 6, No 3
DOI: https://doi.org/10.34865/bi10624e6_3or
✔ 4.3 Reference materials

• 8 Carboxygeraniol ((2E,6E) 8 hydroxy 2,6 dimethylocta 2,6 dienoic acid) (e.g. ChiroBlock GmbH, Wolfen, Germany)
  • 8 Carboxygeraniol d5 ((2E,6E) 8 hydroxy 2 methyl 6 trideuteromethyl 5,5 dideuteroocta 2,6 dienoic acid) (e.g. ChiroBlock GmbH, Wolfen, Germany)
  • Geranic acid ((2E) 3,7 dimethylocta 2,6 dienoic acid) (e.g. ChiroBlock GmbH, Wolfen, Germany)
  • Hildebrandt acid ((2E,6E) dimethylocta 2,6 dienedioic acid) (e.g. ChiroBlock GmbH, Wolfen, Germany)
  • Hildebrandt acid d5 ((2E,6E) 6 trideuteromethyl 2 methylocta 5,5 dideutero 2,6 dienedioic acid) (e.g. ChiroBlock GmbH, Wolfen, Germany)
  • 3 Hydroxycitronellic acid (3 hydroxy 3,7 dimethyl oct 6 enoic acid) (e.g. ChiroBlock GmbH, Wolfen, Germany)

 

★ Precise optical control of gene expression in C. elegans using improved genetic code expansion and Cre recombinase
Lloyd Davis1, Inja Radman2†, Angeliki Goutou1†, Ailish Tynan1, Kieran Baxter1,
Zhiyan Xi1, Jack M O'Shea1, Jason W Chin2*, Sebastian Greiss1*
eLife 2021;0:e67075.
DOI: https://doi.org/10.7554/eLife.67075
✔ Chemical compound: Photocaged lysine (6-nitropiperonyl- L-Lysine)
Source / Reference: ChiroBlock GmbH; Gautier et al., 2010
CAS number: 1221189-11-2, Custom synthesised by ChiroBlock GmbH, Germany. Synthesis described in Gautier et al. (10.1021/ja910688s)

★ Using a Quadruplet Codon to Expand the Genetic Code of an Animal
Zhiyan Xi, Lloyd Davis, Kieran Baxter, Ailish Tynan, Angeliki Goutou, Sebastian Greiss
BioRxiv
doi: https://doi.org/10.1101/2021.07.17.452788

★ Photocaged lysine (PCK) and photocaged cysteine (PCC) were custom synthesized by ChiroBlock GmbH.
In vivo bioavailability and in vitro toxicological evaluation of the new butyric acid releaser N-(1-carbamoyl-2-phenyl-ethyl) butyramide
Roberto Russoa1, Cristina Santarcangeloa1, Nadia Badolatia, Eduardo Sommellab, AnnaDe Filippisa, Marco Dacremaa, Pietro Campigliabc, Mariano Stornaiuoloa, Maria Dagliaad
Biomedicine & Pharmacotherapy, Volume 137, May 2021, 111385
✔ Chemicals: Two industrial batches of FBA (N° UNF 5038b4I and N° UNF 5038b6I) were provided by ChiroBlock® (Wolfen, Germany).

★ Atmospheric photooxidation and ozonolysis of Δ3-carene and 3-caronaldehyde: rate constants and product yields
Luisa Hantschke, Anna Novelli, Birger Bohn, Changmin Cho, David Reimer, Franz Rohrer, Ralf Tillmann, Marvin Glowania, Andreas Hofzumahaus, Astrid Kiendler-Scharr, Andreas Wahner, and Hendrik Fuchs
Atmos. Chem. Phys., 21, 12665–12685, 2021
https://doi.org/10.5194/acp-21-12665-2021
✔ Materials: Caronaldehyde was synthesized by ChiroBlock GmbH (Wolfen, Germany) as an enantiomeric mixture of (+)- and (−)-caronaldehyde with a purity of >95 % determined by 1H-NMR measurements.

★ Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
Ritamaria di Lorenzo1, Antonietta Bernardi1, Lucia Grumetto1, Antonia Sacchi1, Carmen Avagliano1, Serena Coppola2,3, Anna Fiorenza de Giovanni di Santa Severina2,3, Cristina Bruno2,3, Lorella Paparo2,3, Sonia Laneri1,* and Irene Dini1,*
Molecules 2021, 26(21), 6611
https://doi.org/10.3390/molecules26216611
✔ Reagent and Chemicals: Phenylalanine butyramide (FBA) (C13H18N2O2) (234.29 g/mol) (US patent US 2011 00983.19A1; 28 April 2011) was bought by ChiroBlock® (Wolfen, Germany).

★ One-Step Synthesis of Triphenylphosphonium Salts from (Het)arylmethyl Alcohols
Petrakis N. Chalikidi*, Taimuraz T. Magkoev, Andrey V. Gutnov, Oleg P. Demidov, Maxim G. Uchuskin*, Igor V. Trushkov, and Vladimir T. Abaev
J. Org. Chem. 2021, 86, 14, 9838–9846
https://doi.org/10.1021/acs.joc.1c00733

★ Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly
Daniel Horn-Ghetko, David T. Krist, J. Rajan Prabu, Kheewoong Baek, Monique P. C. Mulder, Maren Klügel, Daniel C. Scott, Huib Ovaa, Gary Kleiger & Brenda A. Schulman
Nature volume 590, pages 671–676 (2021)
https://doi.org/10.1038/s41586-021-03197-9
✔ The basis for the formation of the TS1 ABP–UBE2L3~Ub was coupling His–Ub(1–75)–MESNa to (E)-3-[2-(bromomethyl)-1,3-dioxolan-2-yl]prop-2-en-1-amine (BmDPA) (>95% purity, ChiroBlock) to yield a reactive species4.

★ Acetylation turns leucine into a drug by membrane transporter switching
Grant C. Churchill, Michael Strupp, Cailley Factor, Tatiana Bremova-Ertl, Mallory Factor, Marc C. Patterson, Frances M. Platt & Antony Galione
Scientific Reports volume 11, Article number: 15812 (2021)
https://doi.org/10.1038/s41598-021-95255-5
✔ N-acetyl-d,l-[2H10]leucine was obtained from ChiroBlock (Andresenstraße, Germany)

★ Genetically Encoding Light-Responsive Protein-Polymers Using Translation Machinery for the Multi-Site Incorporation of Photo-Switchable Unnatural Amino Acids
Bar Israeli, Daniela S. Strugach, Sigal Gelkop, Shir Weber, Dor S. Gozlan, Miriam Amiram
Advanced Functional Materials, 2021, Volume31, Issue44
https://doi.org/10.1002/adfm.202011276
✔ Materials: The […] azobenzene-uAA 3 was purchased from ChiroBlock.

★ Brain glycogen serves as a critical glucosamine cache required for protein glycosylation
Ramon C. Sun1,3, Lyndsay E.A. Young2,3, Ronald C. Bruntz2, Kia H. Markussen2, Zhengqiu Zhou2, Lindsey R. Conroy1,3, Tara R. Hawkinson1, Harrison A. Clarke1, Alexandra E. Stanback1, Jessica K.A. Macedo2, Shane Emanuelle2, M. Kathryn Brewer2,4, Alberto L. Rondon2, Annette Mestas2, William C. Sanders2, Krishna K. Mahalingan5, Buyun Tang5, Vimbai M. Chikwana5, Dyann M. Segvich5, Christopher J. Contreras5, Elizabeth J. Allenger6, Christine F. Brainson7, Lance A. Johnson6, Richard E. Taylor8, Dustin D. Armstrong9, Robert Shaffer10, Charles J. Waechter2, Craig W. Vander Kooi2,3, Anna A. DePaoli-Roach5, Peter J.Roach5, Thomas D. Hurley5, Richard R. Drake11, Matthew S. Gentry2,3,12
Cell Metabolism, Volume 33, Issue 7, 6 July 2021, Pages 1404-1417.e9
https://doi.org/10.1016/j.cmet.2021.05.003
✔ Glucose 3-phosphate Chiroblock

★ High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology
Nina Braun, Søren Friis, Christian Ihling, Andrea Sinz, Jacob Andersen, Stephan A. Pless
PLOS BIOLOGY, 2021
https://doi.org/10.1371/journal.pbio.3001321
✔ Bpa-methylester (for synthesis and mass spectrometric incorporation analysis, see S1 Text) or 100 μM Se-AbK (custom-synthesized by ChiroBlock, Germany).

★ Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death
Nina Meyer, Lisa Henkel, Benedikt Linder, Svenja Zielke, Georg Tascher, Sandra Trautmann,
Gerd Geisslinger, Christian Münch, Simone Fulda, Irmgard Tegeder & Donat Kögel
Autophagy, 2021
https://doi.org/10.1080/15548627.2021.1874208
✔ Product number: 860,677, C24Cer-d4 – Chiroblock GmbH, Wolfen, Germany; custom synthesis

★ The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model
Felix Wiedmann1,2,3†, Christoph Beyersdorf1,3†, Xiao-Bo Zhou2,4, Manuel Kraft1,2,3, Kathrin I. Foerster5, Ibrahim El-Battrawy2,4, Siegfried Lang2,4, Martin Borggrefe2,4, Walter E. Haefeli5, Norbert Frey1,2,3 and Constanze Schmidt1,2,3*
Front. Physiol., 21 January 2021
https://doi.org/10.3389/fphys.2020.629421
✔ A293 was synthesized by ChiroBlock (ChiroBlock, Wolfen, Germany) with a purity of 98%

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2020

★ Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model
Felix Wiedmann, Christoph Beyersdorf, Xiaobo Zhou, Antonius Büscher, Manuel Kraft, Jendrik Nietfeld, Teo Puig Walz, Laura A. Unger, Axel Loewe, Bastian Schmack, Arjang Ruhparwar, Matthias Karck, Dierk Thomas, Martin Borggrefe, Gunnar Seemann, Hugo A. Katus, and Constanze Schmidt
Originally published9 May 2020, Journal of the American Heart Association. 2020;9:e015751
https://doi.org/10.1161/JAHA.119.015751
✔ The aromatic carbonamide A293 2‐(butylsulfonylamino)‐N‐[(1R)‐1‐(6‐methoxy‐3‐pyridyl)propyl]‐benzamide has been synthesized by ChiroBlock (ChiroBlock, Wolfen, Germany) with a purity of 98%.

★ Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)
Mateusz Adam Krzyscik, Małgorzata Zakrzewska, and Jacek Otlewski*
Mol. Pharmaceutics 2020, 17, 7, 2734–2748
https://doi.org/10.1021/acs.molpharmaceut.0c00419
✔ Reagents: The cytotoxic agents, auristatin Y (AY) and maleimidocaproyl-threonine-valine-auristatin Y (tvAY), were from custom synthesis carried out by ChiroBlock GmbH (Wolfen, Germany).

★ Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry
Lyndsay E.A.YoungaCorey O.BrizzeeaJessica K.A.MacedoaRobert D.MurphyaChristopher J.ContrerasdeAnna A.DePaoli-RoachdePeter J.RoachdeMatthew S.GentryacefRamon C.Sunbf
Carbohydrate Polymers Volume 230, 15 February 2020, 115651
https://doi.org/10.1016/j.carbpol.2019.115651
✔ Materials: Glucose-3-phosphate synthesized by Chiroblock

★ Synthetic biology yields a dinuclear copper based antibody for the naked-eye detection of glyphosate
Marc Creus1* and Thibaud Rossel2†
ChemRxiv, Apr. 2020
https://doi.org/10.26434/chemrxiv.12143850.v2
✔ Ligand synthesis: Ligand synthesis was performed by Chiroblock Germany.

★ Quantitative determination of urinary metabolites of geraniol by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)
Thomas Jäger,*a Sandra Bäcker,a Thomas Brodbeck,a Edgar Leiboldb and Michael Badera
Anal. Methods, 2020,12, 5718-5728
https://doi.org/10.1039/D0AY01582B
✔ Chemicals: (2E,6E)-2,6-Dimethyl-octa-2,6-diene-1,8-diol (8-hydroxygeraniol), (2E,6E)-8-hydroxy-2,6-dimethyl-octa-2,6-dienoic acid (8-carboxygeraniol), (2E,6E)-2,6-dimethyl-octa-2,6-dienedioic acid (Hildebrandt acid), (E)-3,7-dimethyl-octa-2,6-dienoic acid (geranic acid) and 3-hydroxy-3,7-dimethyl-oct-6-enoic acid (3-hydroxycitronellic acid) as well as the deuterated internal standards (2E,6E)-6-trideuteromethyl-2-methyl-octa-5,5-dideutero-2,6-dienedioic acid (d5-Hildebrandt acid) and (2E,6E)-8-hydroxy-2-methyl-6-trideuteromethyl-5,5-dideutero-octa-2,6-dienoic acid (d5-8-carboxygeraniol) were custom-synthesized in the laboratory of Chiroblock® (Wolfen, Germany).

★ Synthesis of lipid-linked oligosaccharides by a compartmentalized multi-enzyme cascade for the in vitro N-glycosylation of peptides
Thomas F.T. Rexera, Lisa Wenzela, Marcus Hoffmanna, Sebastian Tischlika, Christin Bergmannb, Valerian Grotea, Simon Boeckerc, Katja Bettenbrockc, Anna Schildbachb, Robert Kottlerae, Reza Mahoura, Erdmann Rappae, Markus Pietzschb, Udo Reichlad
Journal of Biotechnology, Volume 322, 10 October 2020, Pages 54-65
https://doi.org/10.1016/j.jbiotec.2020.07.003
✔ Materials: Phytanylpyrophosphorylchitobiose(LL-(GlcNAc)2)was used as a precursor for the invitro synthesis of lipid-linked Man5. The compound was chemically synthesized and purchased from ChiroBlock GmbH (Bitterfeld-Wolfen,Germany)

★ Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
Emilia Waraksaab, Katarzyna Owczareka, Paweł Kubicaa, Ewa Kłodzińskab, Mariusz Ozimekb, Robert Wrzesieńc, Barbara Bobrowska-Korczakd, Jacek Namieśnika1
Journal of Chromatography B, Volume 1151, 15 August 2020, 122197
https://doi.org/10.1016/j.jchromb.2020.122197
✔ Standards and reagents: Racemic-4-(2-amino-3,5-dibromobenzylamino)cyclohexanol (4-HDMB), racemic-3-(2-amino-3,5-dibromobenzylamino)cyclohexanol (3-HDMB), racemic-2-(2-amino-3,5-dibromobenzylamino)cyclohexanol (2-HDMB) were purchased from ChiroBlock GmbH (Bitterfeld Wolfen, Germany).

★ Validation of a method for the determination of triphenylmethane dyes in trout and shrimp with superior extraction efficiency
Jürgen Eich, Detlef A. Bohm, Dagmar Holzkamp & Joachim Mankertz
Food Additives & Contaminants: Part A Volume 37, 2020 - Issue 1
https://doi.org/10.1080/19440049.2019.1671611
✔ Chemicals and reagents: The substance […] 13C6-leuco brilliant green (13C6-LBG) was supplied by ChiroBlock (Wolfen, Germany).

★ iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis
Jonatan Darr1,.2, Archana Tomar1, 2. Maximilian Lassi1, 2, Raffaele Gerlini1, 2, Lucia Berti2, 6, Annette Hering1, Fabienne Scheid1, 2, Martin Hrabě de Angelis1, 2, 3, Michael Witting4, 5, Raffaele Teperino1, 2, 7
Cell Reports, Volume 30, Issue 9, 3 March 2020, Pages 3183-3194.e4
https://doi.org/10.1016/j.celrep.2020.02.020
✔ HD5EU was synthesized by Chiroblock; the identity of the final product was validated using mass spectrometry (MS), p-NMR, and h-NMR; and the molecule’s purity was assessed as more than 98% (Figure S1).

★ Lead Optimization of Dehydroemetine for Repositioned Use in Malaria
Priyanka Panwar, Kepa K. Burusco, Muna Abubaker, Holly Matthews, Andrey Gutnov, Elena Fernández-Álvaro, Richard A. Bryce, James Wilkinson, and Niroshini Nirmalan
Antimicrobial Agents and Chemotherapy, 2020, Vol. 64, No. 4
https://doi.org/10.1128/AAC.01444-19
✔ Synthesis of (−)-2,3-dehydroemetine: (−)-2,3-Dehydroemetine was synthesized according to the methods in the established literature (16, 53). The synthesis was outsourced to Chiroblock GMBH, Germany.

★ Polycationic oligomers and polymers as broad-spectrum conserving agent for medicinal products for use on the eye
Dörte von Deylen
Dissertation, TU Braunschweig, 2020

★ Effect of allosteric inhibition of non-muscle myosin 2 on its intracellular diffusion
Ádám I. Horváth, Máté Gyimesi, Boglárka H. Várkuti, Miklós Képiró, Gábor Szegvári, István Lőrincz, György Hegyi, Mihály Kovács & András Málnási-Csizmadia
Scientific Reports volume 10, Article number: 13341 (2020)
https://doi.org/10.1038/s41598-020-69853-8
✔ Chemicals: para-Nitroblebbistatin (pNbleb) and azidoblebbistatin (N3Bleb) were synthesized by ChiroBlock GmbH.

★ Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation
Khadija El-Hindi1,†, Sebastian Brachtendorf1,†, Jennifer Christina Hartel1,2, Stephanie Oertel1,
Kerstin Birod1, Sandra Trautmann1, Dominique Thomas1, Thomas Ulshöfer3, Andreas Weigert4, Olaf Utermöhlen5, Martin Krönke5 and Sabine Grösch1,*Cancers 2020, 12(7), 1753;
https://doi.org/10.3390/cancers12071753
✔ Chemicals: […] C24:0 Cer-d4 (Chiroblock GmbH, Bitterfeld-Wolfen, Germany; 400 ng/mL each).

★ Biochemical Characterisation of glycosyltransferase Dpm1 from S. cerevisiae and in vitro Dolichylphosphatmannose production
Schöpfer, Matthias
Martin-Luther-Universität Halle-Wittenberg
Ph.D. Thesis, 2020
http://dx.doi.org/10.25673/32303
✔ Phytanylphosphat: ChiroBlock, Wolfen

★ Untersuchungen zur Synthese von Biopolymeren unter Einsatz von Biokatalysatoren in parallelen Multienzym‐Multisubstrat‐Reaktionen
Schildbach, Anna; Martin-Luther-Universität Halle-Wittenberg;
Ph.D. Thesis, 2020
http://dx.doi.org/10.25673/34910
✔ The retention times were determined and the MS parameters were optimized using
analytical standards in high purity (Sigma Aldrich, Hamburg, Germany; ChiroBlock
GmbH, Bitterfeld, Germany).

★ Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model
Felix Wiedmann, Christoph Beyersdorf, Xiaobo Zhou, Antonius Büscher, Manuel Kraft, Jendrik Nietfeld, Teo Puig Walz, Laura A. Unger, Axel Loewe, Bastian Schmack, Arjang Ruhparwar, Matthias Karck, Dierk Thomas, Martin Borggrefe, Gunnar Seemann, Hugo A. Katus and Constanze Schmidt
Journal of the American Heart Association. 2020;9:e015751
https://doi.org/10.1161/JAHA.119.015751

---

2019

★ Vitamin D effects on sphingosine 1-phosphate signaling and metabolism in monocytes from type 2 diabetes patients and controls
Nojan Nejatian, Sandra Trautmann, Dominique Thomas, Josef Pfeilschifter, Klaus Badenhoop, Alexander Koch, Marissa Penna-Martinez,
The Journal of Steroid Biochemistry and Molecular Biology, 186, 2019, 130-135
https://doi.org/10.1016/j.jsbmb.2018.10.005

---

2018

★ An Optically Programmable Surface Realized With Azobenzene-Functionalized Lotus Leaf and OLEDs
M. Bremer, C. Kallweit, A. F. K. Iwers and M. Gerken
IEEE Photonics Technology Letters, 2018 vol. 30, no. 8, pp. 673-676
https://doi.org/10.1109/LPT.2018.2811041

★ The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.
Jennifer Kurz, Robert Brunkhorst, Christian Foerch, Leonard Blum, Marina Henke, Laureen Gabriel, Thomas Ulshöfer, Nerea Ferreirós, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann
Clin Sci (Lond) 2018; 132 (17): 1963–1976.
doi: https://doi.org/10.1042/CS20180506

★ Alteration of sphingolipid metabolism as a putative mechanism underlying LPS-induced BBB disruption
Vutukuri, R., Brunkhorst, R., Kestner, R.-I., Hansen, L., Bouzas, N.F., Pfeilschifter, J., Devraj, K. and Pfeilschifter, W.
J. Neurochem., (2018) 144: 172-185
https://doi.org/10.1111/jnc.14236

---

2017

★ Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1
Sochaj-Gregorczyk, A.M.; Ludzia, P.; Kozdrowska, E.; Jakimowicz, P.; Sokolowska-Wedzina, A.; Otlewski, J.
Int. J. Mol. Sci. 2017, 18, 1688.
https://doi.org/10.3390/ijms18081688

★ Nuclear translocation of SGPP-1 and decrease of SGPL-1 activity contribute to Sphingolipid rheostat regulation of inflammatory dendritic cells
Schwiebs, A., Thomas, D., Kleuser, B., Pfeilschifter, J. M., Radeke, H. H.
Mediators of inflammation, 2017(1), 5187368.
https://doi.org/10.1155/2017/5187368

★ Sphingosine-1-phosphate receptor 5 modulates early-stage processes during fibrogenesis in a mouse model of systemic sclerosis: a pilot study
Schmidt, K. G., Herrero San Juan, M., Trautmann, S., Berninger, L., Schwiebs, A., Ottenlinger, F. M., Thomas,D., Zaucke, F., Pfeilschifter, J. Radeke, H. H.
Frontiers in immunology, (2017) 8, 1242.
https://doi.org/10.3389/fimmu.2017.01242

★ NRAP-1 is a presynaptically released NMDA receptor auxiliary protein that modifies synaptic strength
Lei, N., Mellem, J. E., Brockie, P. J., Madsen, D. M., Maricq, A. V.
Neuron, (2017) 96(6), 1303-1316.
https://doi=10.1016/j.neuron.2017.11.019

★ Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients
Koch, A.; Grammatikos, G.; Trautmann, S.; Schreiber, Y.; Thomas, D.; Bruns, F.; Pfeilschifter, J.; Badenhoop, K.; Penna-Martinez, M.
Int. J. Mol. Sci. 2017, 18, 1532.
https://doi.org/10.3390/ijms18071532

★ Major sulfonate transporter Soa1 in Saccharomyces cerevisiae and considerable substrate diversity in its fungal family
Holt, S., Kankipati, H., De Graeve, S., Van Zeebroeck, G., Foulquié-Moreno, M. R., Lindgreen, S., Thevelein, J. M
Nature Communications, (2017) 8(1), 14247
https://doi.org/10.1038/ncomms14247

★ Expositionsversuche an Sprague-Dawley Ratten zur Untersuchung des Metabolismus von 1-Vinyl-2-pyrrolidon mit dem Ziel der Etablierung einer Human-Biomonitoring Methode
Bertram, J. (2017).
Dissertation, RWTH Aachen University, 2017
https://10.18154/RWTH-2018-00213

★ Quantification of six potential unspecific human biomarkers of 1-vinyl-2-pyrrolidone exposure in Sprague-Dawley rat urine using gas chromatography coupled with triple mass spectrometry
Bertram, J., Schettgen, T., Kraus, T.
Rapid Communications in Mass Spectrometry, (2017) 31(21), 1851-1858
https://doi.org/10.1002/rcm.7972

★ Ammoxidized Fenton-Activated Pine Kraft Lignin Accelerates Synthesis and Curing of Resole Resins
Ghorbani, M., Konnerth, J., Budjav, E., Requejo Silva, A., Zinovyev, G., Van Herwijnen, H. W., Edler, M., Griesser, T., Liebner, F.
Polymers, 2017, 9(2), 43
https://doi.org/10.3390/polym9020043

★ Molecular Basis for Allosteric Inhibition of Acid-Sensing Ion Channel 1a by Ibuprofen
Lynagh, T., Romero-Rojo, J. L., Lund, C., Pless, S.A.
J. Med. Chem. 2017, 60, 19, 8192–8200
https://doi.org/10.1021/acs.jmedchem.7b01072

---

2016

★ A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2 + Cell Lines
Sochaj-Gregorczyk, A. M., Serwotka-Suszczak, A. M., & Otlewski, J.
Journal of Immunotherapy, 2016, 39(6), 223–232.
https://doi:10.1097/cji.0000000000000125

★ Furan ring as a surrogate for carboxy group (microreview)
Gutnov, A.
Chemistry of Heterocyclic Compounds, (2016), 52(2), 87-89.
https://doi.org/10.1007/s10593-016-1836-4

---

2015

★ Understanding the ionic liquid [NC 4111][NTf 2] from individual building blocks: an IR-spectroscopic study
Hanke, K., Kaufmann, M., Schwaab, G., Havenith, M., Wolke, C. T., Gorlova, O., Johnson, M.A., Kar, B. P., Sander, W. & Sanchez-Garcia, E.
Physical Chemistry Chemical Physics, (2015) 17(13), 8518-8529
https://doi.org/10.1039/C5CP00116A

---

2012

★ Deuterium-L-Dopa: a Novel Means to Improve Treatment of Parkinson´ s Disease
Malmlöf, Torun
Karolinska Institutet (Sweden), 2012

---

2011

★ Mercapturic acids as metabolites of alkylating substances in urine samples of German inhabitants
Eckert, E., Schmid, K., Schaller, B., Hiddemann-Koca, K., Drexler, H., & Göen, T.
International journal of hygiene and environmental health, (2011), 214(3), 196-204.
https://doi.org/10.1016/j.ijheh.2011.03.001

★ Entwicklung und Anwendung analytischer Methoden zur Bestimmung von Merkaptursäuren im menschlichen Urin als Metabolite wichtiger alkylierender Verbindungen
Eckert, Elisabeth
Friedrich-Alexander-Universitaet Erlangen-Nuernberg (Germany), 2011

---

2010

★ Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology
Martin, R., Entchev, E. V., Kurzchalia, T. V., & Knölker, H. J.
Organic & Biomolecular Chemistry, (2010) 8(4), 739-750
https://doi.org/10.1039/B918488K

★ Determination of six hydroxyalkyl mercapturic acids in human urine using hydrophilic interaction liquid chromatography with tandem mass spectrometry (HILIC–ESI-MS/MS)
Eckert, Elisabeth, Hans Drexler, and Thomas Göen
Journal of Chromatography B 878.27 (2010): 2506-2514.
https://doi.org/10.1016/j.jchromb.2009.09.003

★ Mechanism of amphoteric liposomes & application for siRNA delivery
Siepi, Evgenios
Diss. Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Diss., 2010, 2010

---

2009

★ Amphoteric Liposomes Enable Systemic Antigen-Presenting Cell–Directed Delivery of CD40 Antisense and Are Therapeutically Effective in Experimental Arthritis
Evangelos Andreakos; Una Rauchhaus; Athanassios Stavropoulos; Gerold Endert; Volkmar Wendisch; Amina S. Benahmed; Stavros Giaglis; James Karras; Sam Lee; Hans Gaus; C. Frank Bennett; Richard O. Williams; Paschalis Sideras; Steffen Panzner
experimental arthritis. (2009) , 60(4), 994–1005.
https://doi.org/10.1002/art.24434

★ Aryl Ring Migration Reaction in the Synthesis of 2,4-Diaryl-4H-3,1-benzothiazines
Alexander V. Butin, Fatima A. Tsiunchik, Vladimir T. Abaev, Andrey V. Gutnov, Dmitry A. Cheshkov
Synthesis 2009(15): 2616-2626
https://doi.org/10.1055/s-0029-1217399

---

2008

★ Palladium-Catalyzed Asymmetric Conjugate Addition of Aryl–Metal Species
Andrey Gutnov
Eur. JOC, 2008, Issue 27, 4547-4554
https://doi.org/10.1002/ejoc.200800541

★ Regulation of aspartate-derived amino acid homeostasis in potato plants (Solanum tuberosum L.) by expression of E. coli homoserine kinase
Rinder, J., Casazza, A., Hoefgen, R. et al.
Amino Acids 34, 213–222 (2008)
https://doi.org/10.1007/s00726-007-0504-5

★ Altered behavioural and neurochemical profile of l-DOPA following deuterium substitutions in the molecule
Torun Malmlöf, Torgny H. Svensson, Björn Schilström
Experimental Neurology, Volume 212, Issue 2, August 2008, Pages 538-542
https://doi.org/10.1016/j.expneurol.2008.05.003

★ Synthesis of Chiral Pyridyl Alcohols by Cyclotrimerization
Victor Snieckus, Wei Gan, B. Heller, D. Redkin, A. Gutnov, C. Fischer, W. Bonrath, R. Karge, M. Hapke
Synfacts 2008(3):0235-0235
https://doi.org/10.1055/s-2008-1042749

★ Synthesis of Chiral Pyridyl Alcohols Using a Two-Step Catalytic Approach
Barbara Heller, Dmitry Redkin, Andrey Gutnov, Christine Fischer, Werner Bonrath, Reinhard Karge, Marko Hapke
Synthesis 2008(1): 69-74
https://doi.org/10.1055/s-2007-990903

★ New pyridine N-oxides as chiral organocatalysts in the asymmetric allylation of aromatic aldehydes
Andrei V. Malkov, Mary-Margaret Westwater, Andrey Gutnov, Pedro Ramírez-López, Frédéric Friscourt, Aneta Kadlčíková, Jana Hodačová, Zoran Rankovic, Martin Kotora
Tetrahedron, Volume 64, Issue 49, 1 December 2008, Pages 11335-11348
https://doi.org/10.1016/j.tet.2008.08.084

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2007

★ Synthesis of (E)-2,3′,4,5′-tetramethoxy[2-11C]stilbene
Lutz Schweiger, Stuart Craib, Andrew Welch, Tim A. D. Smith
J. Labelled Compounds & Radiopharmaceuticals, Volume 50, Issue 13, November 2007, Pages 11206–1210
https://doi.org/10.1002/jlcr.1439

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2003

★ Functional Analysis of Cystathionine γ-Synthase in Genetically Engineered Potato Plants
Kreft, O.; Hoefgen,R.; Hesse, H.
Plant Physiology, Volume 131, Issue 4, April 2003, Pages 1843–1854,
https://doi.org/10.1104/pp.102.015933