ChiroBlock GmbH provides a professional Chemical Custom Synthesis Service dedicated to the needs of academic research groups, universities, and public research institutions.

We support scientific projects where molecules are not commercially available, synthesis routes are challenging, or internal resources are limited.

➽ Submit your synthesis request today
➽ Discuss your research project with our chemists

Supporting Academic Research with Chemical Custom Synthesis

Academic research often requires novel compounds, reference materials, or specifically functionalized molecules to validate hypotheses, publish results, or progress funded projects. Our Chemical Custom Synthesis Service is designed to support exactly these challenges.

We collaborate closely with academic scientists to deliver tailor-made compounds while ensuring transparency, feasibility, and scientific rigor.

➽ Request a custom synthesis quote for your research project

Why Academic Researchers Choose ChiroBlock

➽ Tailor-Made Chemical Custom Synthesis Service

We synthesize compounds that are not commercially available, based on your structure, publication goals, or experimental needs. Each project is evaluated individually to ensure scientific feasibility and optimal routes.

➽ From Milligrams to Larger Research Quantities

Our Chemical Custom Synthesis Service supports projects from few milligrams for early-stage research up to larger quantities for ongoing academic programs.

➽ Scientific Collaboration & Transparency

We work as an extension of your research team, providing clear communication, realistic timelines, and transparent cost structures—essential for grant-funded projects.

➽ Confidentiality & IP Protection

Protecting intellectual property is essential in academic research. ChiroBlock is happy to sign CDA/NDA agreements to ensure confidential and trust-based collaboration.

➽ Contact us to discuss confidentiality and project scope

Chemical Custom Synthesis Capabilities for Academia

Our Chemical Custom Synthesis Service for academic research includes:

• First-time synthesis of novel molecules
• Reference compounds and analytical standards
• Labelled and functionalized compounds
• Medicinal chemistry and complex small molecules
• Route scouting and feasibility studies
• Synthesis optimization for reproducibility

All synthesis is supported by appropriate analytical characterization to ensure reliability and scientific validity.

➽ Send us your molecule structure to get started

A Structured Chemical Custom Synthesis Service Process

Our process is designed to fit the workflows of academic research projects:

1. Submission of your molecule and requirements
2. Scientific evaluation and route assessment
3. Transparent quotation and timeline
4. Chemical synthesis and analytical validation
5. Delivery with full documentation

This structured Chemical Custom Synthesis Service helps researchers plan experiments, meet publication deadlines, and support funding milestones.

➽ Start your custom synthesis project today

Experienced Partner for Academic Chemical Synthesis

With more than 25 years of experience in chemical synthesis and contract research, ChiroBlock supports academic partners worldwide. Our fully equipped synthesis laboratories and kilo labs allow us to handle complex chemistry challenges with high scientific standards.

ChiroBlock’s Chemical Custom Synthesis Service is trusted by leading academic and research institutions worldwide. Our work supports projects conducted at internationally renowned organizations such as:

• Harvard University
• Massachusetts Institute of Technology
• Stanford University
• University of Oxford
• University of Cambridge
• ETH Zurich
• California Institute of Technology
• Imperial College London
• Max Planck Society
• Fraunhofer Society
• Helmholtz Association
• CNRS
• Johns Hopkins University
• Karolinska Institute
• and many more ...

These collaborations reflect our ability to meet the highest scientific standards while operating with the professional reliability, confidentiality, and project discipline required by globally recognized research institutions. By combining academic rigor with a business-oriented project approach, ChiroBlock enables researchers to advance complex scientific objectives efficiently and with confidence.

We understand the constraints of academic research—and provide solutions that are reliable, flexible, and publication-ready.

➽ View all publications & references

Ready to Advance Your Research with a Chemical Custom Synthesis Service?

Whether you need a novel compound for a publication, a reference molecule for validation, or specialized chemistry support, ChiroBlock is your trusted partner.

➽ Request a custom synthesis quote
➽ Arrange a video meeting or callback
➽ Submit your molecule and specifications now

ChiroBlock – Your Chemical Custom Synthesis Service Partner for Academic Research

Recent Scientific Publications & References Involving Custom-Synthesized Molecules by ChiroBlock

For more than 25 years, ChiroBlock has specialized in the synthesis of commercially not available compounds for academic R&D, supporting universities, research institutes, and innovation-driven laboratories worldwide. Our expertise includes complex custom synthesis projects for pharmaceutical research, biotechnology, functional materials, and advanced synthetic chemistry, contributing to numerous scientific collaborations and peer-reviewed publications.

Because many projects involving the synthesis of commercially not available compounds for academic R&D are linked to unpublished research and sensitive intellectual property, we work under strict confidentiality and IP protection agreements. Therefore, we can only reference scientific projects and publications that have been independently published by our academic or industrial partners and explicitly mention ChiroBlock.

2026

★ Human biomonitoring of 2,4-di-tert-butylphenol: determination of the parent substance and a novel, specific metabolite in urine by UHPLC-MS/MS
Christoph Schmidtkunz, Katja Küpper, Frank Leßmann, Volkmar Wendisch, Oliver Seidelmann, Edgar Leibold, Melanie Flach, Isabell Schönrath & Gabriele Leng
Anal Bioanal Chem 418, 247–260 (2026)
https://doi.org/10.1007/s00216-025-06217-z

★ Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models
Joshua Abd Alla, Alexander Perhal, Xuebin Fu, Andreas Langer, Yasser el Faramawy, Ursula Quitterer
Cell Reports Medicine, 2026; 7
https://doi.org/10.1016/j.xcrm.2026.102707

★ Expanding the Genetic Code of an Animal with Two Non-Canonical Amino Acids
Jose Javier Vazquez Rodriguez, Sebastian Greiss
BioRxiv
https://www.biorxiv.org/content/10.64898/2026.01.20.700547v1.abstract
https://doi.org/10.64898/2026.01.20.700547

2025

★ In vitro evaluation of 4,4′-trimethylenedipyridinium and 4,4′-trimethylenedipiperidinium-based polycationic polymers against Acanthamoeba hatchetti
Tomas Rimkus, Stephan Reichl
Parasitology Research, Volume 124, 94 (2025)
https://doi.org/10.1007/s00436-025-08537-6

★ Photocaged FLP Recombinase for Precise Spatio-temporal Control of Gene Expression
Jose Javier Vazquez Rodriguez, Kieran Baxter, Sebastian Greiss
bioRxiv 2025.05.06.652468
https://doi.org/10.1101/2025.05.06.652468

★ A UPLC-MS/MS method for the determination of 2-nitro-1,3-propanediol, a metabolite of Bronopol, in human urine
Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Edgar Leibold and Gabriele Leng;
Anal. Methods, 2025,17, 7670-7677
https://doi.org/10.1039/D5AY00960J

★ A new class of natural anthelmintics targeting lipid metabolism
Hala Zahreddine Fahs, Fathima S. Refai, Suma Gopinadhan, Yasmine Moussa, Hin Hark Gan, Yamanappa Hunashal, Gennaro Battaglia, Patricia G. Cipriani, Claire Ciancia, Nabil Rahiman, Stephan Kremb, Xin Xie, Yanthe E. Pearson, Glenn L. Butterfoss, Rick M. Maizels, Gennaro Esposito, Antony P. Page, Kristin C. Gunsalus & Fabio Piano
Nat Commun 16, 305 (2025).
https://doi.org/10.1038/s41467-024-54965-w

★ Percutaneous absorption of climbazole: In vitro data from human skin
Catherine Champmartin, Matthieu Aubertin, Claire Seiwert, Frédéric Cosnier
Regulatory Toxicology and Pharmacology, Volume 162, November 2025, 105895
https://doi.org/10.1016/j.yrtph.2025.105895

★ TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains
Samuel A. Maiwald, Laura A. Schneider, Ronnald Vollrath, Joanna Liwocha, Matthew D. Maletic, Kirby N. Swatek, Monique P. C. Mulder & Brenda A. Schulman
Nature Structural & Molecular Biology volume 32, pages 1766–1775 (2025)
https://doi.org/10.1038/s41594-025-01561-1

★ The performance of an ophthalmic solution containing Poloxamer 407 and Polyquaternium 133 in reducing conjunctival bacterial load in patients receiving cataract surgery, a randomized trial
Alessio Martucci, Elisa Zanotto, Antonio Curtoni, Alessandro Tiezzi Appolloni, Andrea Corsi
European Journal of Ophthalmology. 2025;0(0).
https://doi.org/10.1177/11206721251375236

2024

★ Exposure of young German adults to the anti-dandruff agent climbazole from 2002 to 2022: Analysis of specific biomarkers in urinary samples
Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Till Weber, Gabriele Leng, Marike Kolossa-Gehring; Chemosphere, Volume 367, November 2024, 143611
https://doi.org/10.1016/j.chemosphere.2024.143611

★ Design and Synthesis of Red-Absorbing Fluoran Leuco Dyes Supported by Computational Screening
Deichmann, V.; Chercka, D.; Danner, D.; Rosselli, S.; Nelles, G.; Roberts, A.; Rodin, V.
ACS Omega 2024, 9, 32, 34567–34576
https://doi.org/10.1021/acsomega.4c02646

★ Identification and structural elucidation of an oxidation product generated during stability studies of Cabergoline drug product
Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhuth
Journal of Pharmaceutical and Biomedical Analysis, Volume 248, 15 September 2024, 116282
https://doi.org/10.1016/j.jpba.2024.116282

★ Activation of neurokinin-III receptors modulates human atrial TASK-1 currents
Felix Wiedmann, Amelie Paasche, Jendrik Nietfeld, Manuel Kraft
Journal of molecular and cellular cardiology, Volume 184, p. 26-36, November 2023
https://doi.org/10.1016/j.yjmcc.2023.09.010

★ Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome
El Hindi, K., Brachtendorf, S., Hartel, J. C., Renné, C., Birod, K., Schilling, K., ... & Grösch,
S. BBA-Molecular Basis of Disease, 1870 (2024), 166906
https://doi.org/10.1016/j.bbadis.2023.166906

★ First evidence of widespread anticoagulant rodenticide exposure of the Eurasian otter (Lutra lutra) in Germany
Julia Regnery, Simon Rohner, Julia Bachtin, Christel Möhlenkamp, Olaf Zinke,
Stefanie Jacob, Peter Wohlsein, Ursula Siebert, Georg Reifferscheid, Anton Friesen
Science of the Total Environment 907 (2024) 167938
https://doi.org/10.1016/j.scitotenv.2023.167938

★ Investigation of encapsulated water wire within self-assembled hydrophilic nanochannels, in a modified γ4-amino acid crystals: Tracking thermally induced changes of intermolecular interactions within a crystalline hydrate
Krishnayan Basuroy,Jose de Jesus Velazquez-Garcia, Simone Techert
Amino Acids (2024) 56:9
https://doi.org/10.1007/s00726-023-03372-4

★ Identification, Stability Studies and Structural Elucidation of an Oxidative Degradant of Cabergoline Drug Substance
Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhut
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4704462

★ Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles
Lisa Hahnefeld, Juliane Hackel, Sandra Trautmann, Carlo Angioni, Yannick Schreiber, Robert Gurke, Dominique Thomas, Sabine Wicker, Gerd Geisslinger, Irmgard Tegeder
https://doi.org/10.21203/rs.3.rs-4408378/v1

★ A specific and sensitive GC–MS-MS method for the quantitative determination of 2-phenoxyethanol and selected metabolites in human blood and urine
Jäger, T; Eckert, E.; Leibold, E.; Bader, M.
Journal of Analytical Toxicology, Volume 48, Issue 6, July 2024, Pages 419–428,
https://doi.org/10.1093/jat/bkae037

★ Nonengineered Fungus Provides a Shortcut from Cellulose to Bulk Erythro-isocitric Acid
Schlembach, I.; Bardl,B.; Regestein, R.; Rosenbaum, M.
ACS Sustainable Chem. Eng. 2024, 12, 9, 3408–3418
https://doi.org/10.1021/acssuschemeng.3c04664

★ All-in-one stability indicating polysorbate 20 degradation root-cause analytics via UPLC-QDa
Stefan Carle, Dirk-H. Evers, Elina Hagelskamp, Patrick Garidel, Julia Buske
Journal of Chromatography B 1232 (2024) 123955
https://doi.org/10.1016/j.jchromb.2023.123955

★ Optimierung der Chlorid-Kanalfunktion von mutantem Bestrophin-1
Huttner, L.
Dissertation Uni Regensburg
https://doi.org/10.5283/epub.58290 / https://epub.uni-regensburg.de/58290/

View all publications and References