Looking for a reliable chemical custom synthesis service for challenging molecules, scalable processes, or industrially feasible solutions?

ChiroBlock is your specialized partner for custom chemical synthesis — from early research to pilot and kilogram scale.

With more than 25 years of experience in chemical contract research and custom synthesis, ChiroBlock supports pharmaceutical, biotech, materials, and specialty chemical companies worldwide.

Turn your molecular concept into a reproducible, high-quality compound.

Your Trusted Partner for Chemical Custom Synthesis

ChiroBlock provides tailor-made chemical custom synthesis services for compounds that are not commercially available or require advanced synthetic expertise.

Our services are designed for customers who need:

• Complex or novel molecular structures
• Reliable and reproducible synthesis routes
• Scalable and industrially feasible processes
• Full analytical characterization and documentation

We combine scientific excellence, practical process know-how, and strong quality systems to deliver compounds you can rely on.

Our Chemical Custom Synthesis Capabilities

Advanced Synthetic Expertise

Our team of experienced chemists and PhD scientists specializes in:

• • Multi-step organic synthesis
  • Functional and stereochemically complex molecules
  • Route design, scouting, and optimization
  • Challenging intermediates and final compounds

Every project starts with a feasibility assessment to ensure technical success and economic viability.

Request your free evaluation today

Scalable and Industrially Feasible Processes

A key strength of our chemical custom synthesis service is scalability.

We develop synthesis routes that work not only in the lab but also at:

• Milligram and gram scale
• Kilo lab scale
• Pilot-scale production

This ensures smooth transition from R&D to long-term supply.

Integrated Quality and Analytical Control

ChiroBlock operates under a robust quality management system (ISO 9001) and provides:

• Full analytical characterization (e.g., NMR, HPLC, MS)
• Certificates of Analysis
• Reproducibility and batch-to-batch consistency
• Transparent documentation

Your custom-synthesized compounds are delivered ready for decision-critical research or industrial use.

Why Choose ChiroBlock as Your Chemical Custom Synthesis Service Provider?

• ✔ 25+ years of experience in chemical synthesis services
• ✔ No success, no cost – payment only upon successful synthesis (Fee for Service/ Fee for Result Contract Models)
• ✔ Expertise in complex and high-risk, multi-step synthesis projects
• ✔ Strong expertise in process development and scale-up
• ✔ 100% focused on chemical synthesis services
• ✔ Faster & risk free development of your new products
• ✔ Access to advanced technologies (flow, photochemistry, catalysis)
• ✔ More than 100.000 successfull syntheses
• ✔ Flexible cooperation models (including Fee-for-Service)
• ✔ Full IP protection and confidential collaboration
• ✔ no extra catalogue business - no third party interest
• ✔ owned by employees
• ✔ located in EU/ Germany

ChiroBlock is not a catalogue supplier — we are a scientific partner who understands your chemistry and your business goals.

Request a free Quote here

Applications of Our Chemical Custom Synthesis Service

Our custom synthesis solutions support projects in:

• Pharmaceutical and biotech R&D
• Chemical and materials science
• Electrochromic and functional materials
• Specialty and fine chemicals
• Industrial innovation projects
• Academic Research - Universities & Institutes

Start Your Custom Synthesis Project Today

Whether you need a single complex molecule or a scalable synthesis route, our experts are ready to support you.

➽ Talk to our chemical synthesis experts
➽ Request a confidential project evaluation
➽ Get a reliable and free quote for your custom synthesis needs

Contact ChiroBlock today and discover how our chemical custom synthesis service can accelerate your project — from idea to implementation.

Trusted Chemical Custom Synthesis Expertise Backed by Scientific Publications & Confidential Industry Partnerships

With more than 25 years of experience in chemical custom synthesis, ChiroBlock is a trusted partner for complex and non-commercial molecular challenges in pharma, biotech, materials science, and industrial R&D. Our expertise is reflected in numerous scientific collaborations and customer-related publications.

Due to the highly confidential nature of chemical custom synthesis projects, most of our work is conducted under strict non-disclosure agreements (NDAs) and IP protection frameworks. Therefore, we generally cannot disclose customer names, project details, or internal development data. We only reference projects and publications that have been independently published by our customers with explicit mention of ChiroBlock.

This strict approach to confidentiality, scientific integrity, and IP protection is a core reason why global R&D teams trust ChiroBlock as their partner for advanced chemical custom synthesis and synthetic chemistry projects.

Most Recent Scientific Publications & References Involving Custom-Synthesized Molecules by ChiroBlock

2026

Human biomonitoring of 2,4-di-tert-butylphenol: determination of the parent substance and a novel, specific metabolite in urine by UHPLC-MS/MS
Christoph Schmidtkunz, Katja Küpper, Frank Leßmann, Volkmar Wendisch, Oliver Seidelmann, Edgar Leibold, Melanie Flach, Isabell Schönrath & Gabriele Leng
Anal Bioanal Chem 418, 247–260 (2026)
https://doi.org/10.1007/s00216-025-06217-z

Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models
Joshua Abd Alla, Alexander Perhal, Xuebin Fu, Andreas Langer, Yasser el Faramawy, Ursula Quitterer
Cell Reports Medicine, 2026; 7
https://doi.org/10.1016/j.xcrm.2026.102707

Expanding the Genetic Code of an Animal with Two Non-Canonical Amino Acids
Jose Javier Vazquez Rodriguez, Sebastian Greiss
BioRxiv
https://www.biorxiv.org/content/10.64898/2026.01.20.700547v1.abstract

https://doi.org/10.64898/2026.01.20.700547

2025

In vitro evaluation of 4,4′-trimethylenedipyridinium and 4,4′-trimethylenedipiperidinium-based polycationic polymers against Acanthamoeba hatchetti
Tomas Rimkus, Stephan Reichl
Parasitology Research, Volume 124, 94 (2025)
https://doi.org/10.1007/s00436-025-08537-6

Photocaged FLP Recombinase for Precise Spatio-temporal Control of Gene Expression
Jose Javier Vazquez Rodriguez, Kieran Baxter, Sebastian Greiss
bioRxiv 2025.05.06.652468
https://doi.org/10.1101/2025.05.06.652468

A UPLC-MS/MS method for the determination of 2-nitro-1,3-propanediol, a metabolite of Bronopol, in human urine
Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Edgar Leibold and Gabriele Leng; Anal. Methods, 2025,17, 7670-7677
https://doi.org/10.1039/D5AY00960J

A new class of natural anthelmintics targeting lipid metabolism
Hala Zahreddine Fahs, Fathima S. Refai, Suma Gopinadhan, Yasmine Moussa, Hin Hark Gan, Yamanappa Hunashal, Gennaro Battaglia, Patricia G. Cipriani, Claire Ciancia, Nabil Rahiman, Stephan Kremb, Xin Xie, Yanthe E. Pearson, Glenn L. Butterfoss, Rick M. Maizels, Gennaro Esposito, Antony P. Page, Kristin C. Gunsalus & Fabio Piano
Nat Commun 16, 305 (2025).
https://doi.org/10.1038/s41467-024-54965-w

Percutaneous absorption of climbazole: In vitro data from human skin
Catherine Champmartin, Matthieu Aubertin, Claire Seiwert, Frédéric Cosnier
Regulatory Toxicology and Pharmacology, Volume 162, November 2025, 105895
https://doi.org/10.1016/j.yrtph.2025.105895

TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains
Samuel A. Maiwald, Laura A. Schneider, Ronnald Vollrath, Joanna Liwocha, Matthew D. Maletic, Kirby N. Swatek, Monique P. C. Mulder & Brenda A. Schulman
Nature Structural & Molecular Biology volume 32, pages 1766–1775 (2025)
https://doi.org/10.1038/s41594-025-01561-1

The performance of an ophthalmic solution containing Poloxamer 407 and Polyquaternium 133 in reducing conjunctival bacterial load in patients receiving cataract surgery, a randomized trial
Alessio Martucci, Elisa Zanotto, Antonio Curtoni, Alessandro Tiezzi Appolloni, Andrea Corsi
European Journal of Ophthalmology. 2025;0(0).
https://doi.org/10.1177/11206721251375236

Please find all references for scientific custom synthesis projects here: References & Publications - Custom Synthesis by ChiroBlock.