ChiroBlock provides customized compounds to the scientific community – we are pleased to present the recent publications from our customers!

In a time when research and science face not only budgetary challenges – marked by global resource constraints, shifting funding landscapes and the perpetual demand for innovation research faces some of its toughest conditions in decades.

That is why ChiroBlock is proud to stand behind researchers, scientists and innovators worldwide. Supporting and enabling both basic and applied research in various fields – stretching from medicinal basic research to APIs; to environmental research and environmental analytic.

But see yourself which specific topics ChiroBlock has facilitated with the supply of custom synthesized substances.

Now 2025 is already coming to its closing chapter and we are looking forward to the hopefully positive outcomes of all our customers’ current projects.

For more information on ChiroBlock’s services please visit our website: www.chiroblock.com.

Medicinal basic research:

• Photocaged FLP Recombinase for Precise Spatio-temporal Control of Gene Expression; Vazquez Rodriguez, J. J., Baxter, K., Greiss, S.; bioRxiv05.06.652468
  https://doi.org/10.1101/2025.05.06.652468
• TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains
  Samuel A. Maiwald, Laura A. Schneider, Ronnald Vollrath, Joanna Liwocha, Matthew D. Maletic, Kirby N. Swatek, Monique P. C. Mulder & Brenda A. Schulman
  Nature Structural & Molecular Biology volume32, pages 1766–1775 (2025)
  https://doi.org/10.1038/s41594-025-01561-1
• The performance of an ophthalmic solution containing Poloxamer 407 and Polyquaternium 133 in reducing conjunctival bacterial load in patients receiving cataract surgery, a randomized trial
  Alessio Martucci, Elisa Zanotto, Antonio Curtoni, Alessandro Tiezzi Appolloni, Andrea Corsi
  European Journal of Ophthalmology. 2025;0(0).
  https://doi.org/10.1177/11206721251375236

Active pharmaceutical ingredients:

• In vitro evaluation of 4,4′-trimethylenedipyridinium and 4,4′-trimethylenedipiperidinium-based polycationic polymers against Acanthamoeba hatchetti; Rimkus, T., Reichl, S.; Parasitology Research, Volume 124, 94 (2025)
  https://doi.org/10.1007/s00436-025-08537-6
• A new class of natural anthelmintics targeting lipid metabolism; Fahs, H.Z.; Refai, F.S.; Gopinadhan, S.; Moussa, Y.: Gan, H.H.; Hunashal, Y.; Battaglia, G.; Cipriani, P.G.; Ciancia, C.; Rahiman, N.; Kremb, S.; Xie, X.; Pearson, Y.E.; Butterfoss, G.L.; Maizels, R.M.; Esposito, G.; Page, A. P.; Gunsalus, K.C.; Fabio Piano, F.; Nat Commun 16, 305 (2025).
  https://doi.org/10.1038/s41467-024-54965-w

Environmental research / environmental analytics:

• A UPLC-MS/MS method for the determination of 2-nitro-1,3-propanediol, a metabolite of Bronopol, in human urine; Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Edgar Leibold and Gabriele Leng; Methods, 2025,17, 7670-7677
  https://doi.org/10.1039/D5AY00960J
• Percutaneous absorption of climbazole: In vitro data from human skin
  Catherine Champmartin, Matthieu Aubertin, Claire Seiwert, Frédéric Cosnier
  Regulatory Toxicology and Pharmacology, Volume 162, November 2025, 105895
  https://doi.org/10.1016/j.yrtph.2025.105895
• Human biomonitoring of 2,4-di-tert-butylphenol: determination of the parent substance and a novel, specific metabolite in urine by UHPLC-MS/MS
  Christoph Schmidtkunz, Katja Küpper, Frank Leßmann, Volkmar Wendisch, Oliver Seidelmann, Edgar Leibold, Melanie Flach, Isabell Schönrath & Gabriele Leng
  Anal Bioanal Chem (2025)
  https://doi.org/10.1007/s00216-025-06217-z